They get a Neopar or similar shot at 4 weeks. Then at 6 and again at 8 weeks they get a 5-way shot. And if they have not gone to their new home by age 12 weeks they get a third 5 way shot. Before leaving they see the vet to get a health certificate and from CoffeeCup chihuahua they get a 100% Guarantee against any genetic defects for one year.